About TREMFYA® (guselkumab) for Crohn's Disease

TREMFYA^® is THE ONLY IL-23 blocker that works in two ways

It targets a key component of inflammation called IL-23*^†
It binds to a target on the cells that make IL-23 called CD64^†‡

TREMFYA^® targets IL-23, a key component of inflammation in Crohn’s disease.*^†

TREMFYA^® also binds to a target on the cells that make IL-23 called CD64.^†‡

*Based on laboratory experiments using inflammatory cells.

^†The clinical significance of these findings is unknown.

^‡CD64 are proteins on the surface of certain immune cells, and these cells are the main producers of IL-23 in Crohn’s disease. Cells that do not have CD64 on their surface may also produce IL-23, but to a lesser extent.

”Only” based on approved selective IL-23 blockers for moderately to severely active Crohn’s disease as of March 2025.

CD64=cluster of differentiation 64; IL=interleukin.

TREMFYA^® is THE ONLY IL-23 blocker that works in two ways

It targets a key component of inflammation called IL-23*^†
It binds to a target on the cells that make IL-23 called CD64^†‡

*Based on laboratory experiments using inflammatory cells.

^†The clinical significance of these findings is unknown.

”Only” based on approved selective IL-23 blockers for moderately to severely active Crohn’s disease as of March 2025.

CD64=cluster of differentiation 64; IL=interleukin.

TREMFYA^® targets IL-23, a key component of inflammation in Crohn’s disease.*^†

TREMFYA^® also binds to a target on the cells that make IL-23 called CD64.^†‡

Find a nearby doctor who treats Crohn’s disease

Use this Healthgrades^TM tool to easily find nearby specialists with experience in treating adults with moderately to severely active Crohn’s disease.

Find an Ulcerative Colitis (UC) and Crohn's Disease (CD) specialist on Healthgrades.

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